CYP2C19 and CYP2B6 are thought to be the key cytochrome P450 enzymes involved in the metabolism of sertraline. Unchanged sertraline was not detectable in urine, whereas 12 to 14% of unchanged sertraline was present in feces. In a small study of two males, sertraline was excreted to similar degrees in urine and feces (40 to […]
